ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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Acute exercise increases nitric oxide synthase activity in skeletal muscle. Glutathione is a low molecular weight water-soluble tripeptide composed of cysteine, glutamic acid and glycine, being an important antioxidant and playing a major role in endogenous metabolic products detoxication [ 43 ].

Although NO is, per se, unstable, rapidly exerting its benefits due to its high affinity to various hemecontaining proteins, determining several actions and regulating its biological short half-life, it has no role as a supplement, requiring the ingestion of other compounds that influence internal NO production systems [ 89 ]. Journal of Strength and Conditioning Research24 5 European Journal of Applied Physiology, 5 Unlike the Arg-based studies, all NO 3 studies reported an increase in NOX levels, regardless of whether or not there was a positive performance effect reported.

The physiologic context for potential health benefits. Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man. Actually, physiological L-Arginine concentrations are enough to saturate eNOS, thus, supplementary L-Arginine does not promote increased enzyme activity im 10 ]. Therefore, L-Arginine, as well as its precursor, L-Citrulline, constitutes promising nutrients for the enhancement of white adipose tissue loss in obese individuals [ 41 ].

European Journal of Sport Science12 4 After oral administration, L-Arginine is extensively metabolized by Arginases in the gut wall and liver, increasing blood flow due to the provision of nitric oxide, providing oxygen and nutrients [ 223538 ].

An arterial balloon catheter was inflated in the femoral artery of 1 leg to reduce the postexercise blood flow to the basal pre-exercise rate. NO is also eegogenic in the regulation of contractile force, either directly by gating the sarcoplasmic reticulum calcium release channels, or indirectly by modulating mitochondrial oxidative phosphorylation [ 2930 ].


Potential ergogenic effects of l-arginine fall into 2 general categories: Nutrition on, 22 9 They concluded that the supplement may have increased maximum force and prevented muscle force decline in postmenopausal women.

L-Arginine, a conditionally essential amino acid 2-aminoguanidinovaleric acid that serves functions of relevance to athletes, is the standard L-argunine donor in supplementation and its typical dietary intake is nearly 3. It has been suggested that a possible contribution to tissue reconstruction is NO activation after injury exerts an effect on the expression of myogenic regulatory factors MFRs, like myogenin that occur during recovery [ 32 ].

Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers. Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance.

L-Arginine as a potential ergogenic aid in healthy subjects.

Potential side effects of long-term use of creatine are unknown. The response to an increase in muscle blood flow would likely be different when amino acids are ingested than in the basal state.

This makes it difficult to know if the results of these studies can be attributed to NO supplementation. Arg and Cit supplements that use endogenous NOS to convert Arg to NO have yielded inconsistent results and there are no consistent data from which to make any reliable conclusions.

Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis.

Journal of Applied Physiology6 Despite the undeniable importance of a balanced and highly nutritive diet, there is growing evidence that some supplements can contribute to optimal nutrition [ 3 ]. Interestingly, the liver is capable of synthesizing considerable amounts of L-Arginine, yet this is completely reutilized in the urea l-argibine, being crucial to its normal function [ 22 ].

L-Arginine as a potential ergogenic aid in healthy subjects.

About NOS-independent pathway, it is catalyzed by a wide range of proteins particularly, deoxyhemoglobin present in plasma and other tissues, leading to one-electron reduction of nitrite to NO [ 23 healyhy. In respect to specifically highly trained endurance athletes VO 2max: It has been suggested that this alternative pathway may complement the L-arginine—NOS—NO pathway in conditions resembling skeletal muscle physiology during exercise, by enabling NO production in conditions of low pH NOS function is compromised eegogenic low oxygen availability in which NOS activity which is oxygen dependent may be reduced [ 81723 ].


Interest and drgogenic in the field of NO-producing supplementation for sport performance has grown immensely in the past 30 years. The nature of the relationship between muscle blood flow and muscle protein synthesis is complicated by the fact that in the basal state potenial concentration of EAAs is higher in the intracellular space of muscle than in plasma [e.

Creatine can also be obtained through the diet, mainly from meat and fish. Food sources of nitrates and nitrites: It is known that an L-Arginine infusion at rest increases plasma insulin, glucagon, ergogenci hormone, prolactin and catecolamine concentrations [ 22 ]. Close mobile search navigation Article navigation. Historically, NO has been widely used in clinical settings because of its ptoential effects.

Higher doses of dietary L-Arginine? L-arginine is a conditionally essential amino acid that has received considerable attention due to potential effects on growth hormone secretion and nitric oxide production. The duration of continuous maximal exercise for which nitrate ergogenix to be ergogenic is in the range of min [ 23 ]. Appendix, Table 2 summarizes each study and Table 3 provides an overall summary of the findings.

Journal of Applied Physiology1 Clinical Physiology and Functional Imaging28 5 Whereas arginine alone had no effect, when arginine was added to the balanced amino acid mixture, the rate of muscle protein synthesis as well as net protein balance was significantly stimulated compared to the balanced amino acid mixture.

Scientific opinion of the panel on contaminants in the food chain. However, during periods of rapid growth, or in response to a traumatic or pathologic insult 5 — 7the demand for arginine may not be fully met by de novo synthesis and normal dietary intake alone.

Urea is synthesized from Arginine to enable the body to remove ammonia excess, which is toxic to cells, clarifying the determinant effect of L-Arginine in the recovery from hard training [ 38 – 40 ]. NO 3 -based supplements show the most promise.

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