Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.
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ProtoNet; Automatic hierarchical classification of proteins More Belongs to the JHDM1 histone demethylase family. Using a biochemical assay coupled with chromatography, we have purified a novel JmjC domain-containing protein, JHDM1 JmjC domain-containing histone demethylase 1that specifically demethylates histone H3 at lysine 36 H3-K From This Paper Figures, tables, and topics from this jmjc-ddomain-containing. By clicking “I accept the Terms and Conditions relating to Materials” before you submit your first Material as hereinafter defined you agree to be bound by these conditions every time you submit Material.
Manual assertion based on experiment in i.
JmjC-domain-containing proteins and histone demethylation – Semantic Scholar
Jmjc-domain-containimg disclose any competing interests that might be construed to influence your judgment of the validity or importance nad the article, or any recommendation or review. This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.
Expanding role of the jumonji C domain as an RNA hydroxylase. This is version of the entry and version 2 of the sequence. The Jumonji gene family in Crassostrea gigas suggests evolutionary conservation of Jmj-C histone demethylases orthologues in the oyster gametogenesis and development. Select item s and click on “Add to basket” to create your own collection here entries max.
Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution. Evidence of domain swapping within histonw jumonji family of transcription factors. These are stable identifiers and should be used to cite UniProtKB jmjc-odmain-containing. This family of proteins is broken up into seven distinct subgroups based on domain architecture and their ability to antagonize specific histone methylation marks. You have a close personal relationship e.
Although it was originally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain xnd later found without the JmjN domain in organisms from bacteria to human [ PMID: Institutional access Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution.
See the description of this reaction in Rhea. In the best studied JmjC-domain proteins, the JmjC barrel has a histone demethylase catalytic activity. Select a section on the left to see content.
Examples of ‘Non-Financial Competing Interests’ Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper. Balciunas D, Ronne H. The JmjC has been shown to function in a histone demethylation mechanism that is conserved from yeast to human [ PMID: Topics Discussed in This Paper.
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Histone demethylation by a family of JmjC domain-containing proteins.
All positional information in this entry refers to it. Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Structural insights into histone demethylation by JMJD2 family members. The cupin fold is a flattened beta-barrel structure containing two sheets of five antiparallel beta strands that form the walls of a zinc-binding cleft.
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JmjC-domain-containing proteins and histone demethylation.
Missing in isoform b. Database of Orthologous Groups More Hypoxia-Inducible Histone Lysine Demethylases: Differential intron retention in Jumonji chromatin modifier genes is implicated in reptile temperature-dependent sex determination Ira W. Search chemical reactions in Rhea for this molecule.
Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. N 6N 6 -dimethyl- L -lysine residue. Consider the following examples, but note that this is not an exhaustive list:. Classified as close New Finding 3. Consider the following examples, but note that this is not an exhaustive list: March 7, Last andd update: