Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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Surgical procedures and histopathologic findings for patients with xanthogranulomatous cholecystitis.: J Clin Pathol ; There was no regional lymph node enlargement or focal mass in the liver. Click here for information on linking to our website or using our content or images. Cell composition and xanthogranuomatous possible pathogenetic role of cell-mediated immunity.

Carcinoma of gallbladder Granulomatous cholecystitis Inflammatory myofibroblastic tumor Sarcoma.

Xanthogranulomatous cholecystitis. Histopathological study and classification.

Am J Surg Pathol ;5: J Minim Access Surg 9 3: Cytopathologic diagnosis of xanthogranulomatous cholecystitis and coexistent lesions. XGC may be a high risk of postoperative wound infection and other septic complications because of frequent adhesion and abscess formation.

Gastroenterol Res Pract The pathologic findings showed the collection of foamy histiocytes containing abundant lipid in the cytoplasm and admixed lymphoid cells Fig. Infectious etiology of xanthogranulomatous cholecystitis: Arch Pathoi Lab Med ; Navigation menu Personal tools Log in.

Gallstones are present in most cases. Therefore, obstruction by stones and intraluminal stasis of bile have also been implicated as other important factors 9.

This unusual entity is characterized morphologically by a broad spectrum of xanthogranulomatous changes seen from a small limited focus within yellow nodule in the gallbladder wall, to diffuse involvement of the entire gallbladder with extension of the fibrosis into surrounding tissues. Hepatobiliary Pancreat Dis Int 11 5: The Korean Journal of Internal Medicine ;14 2: On operation, the gallbladder wall was thickened and the serosa were surrounded by dense fibrous adhesions which were often extensive and attached to the adjacent hepatic parenchyma.


Dissection between the gallbladder serosa and hepatic parenchyma was difficult. Pathol Res Pract ; In extensive reports, there is a slightly female predominance, which probably reflects the increased incidence of cholecystitis in women 56.

Accessed December 31st, Retrieved from ” https: After factor VIII replacement, exploration was done. The lesions occur in a wide age range, but the incidence is higher in the sixth and seventh decades of life 67. The pathologic findings showed the collection of foamy histiocytes containing abundant lipid in the cytoplasm and admixed lymphoid cells x Extended chokecystitis resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: Hepatobiliary Pancreat Dis Int.

The pathogenesis of XGC is uncertain, but histologic evidence of chronic inflammation is generally seen and gallstones are present in a large majority of cases. On admission, the patient was febrile and had tenderness on cholecystihis palpation to the right upper quadrant. No metaplasia, dysplasia or significant nuclear atypia is apparent.

Pathology of Xanthogranulomatous Cholecystitis – Dr Sampurna Roy MD

Acta Pathol Jpn ; The precursor lesions of invasive gallbladder carcinoma. A year-old male was admitted to Chonnam National University Hospital with a day history of right upper quadrant pain with fever.

A Case of Xanthogranulomatous Cholecystitis. A clinicopathological study of 20 cases and review of the literature.


It means that both XGC and gallbladder cancer are complications of gallstone and inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall More recently, these terms, together with other labels, such as ceroid granuloma, ceroid-like histiocytic granuloma of the gallbladder 2 and biliary granulomatous cholecystitis 3have been abandoned in favor of XGC, a descriptive term first used by McCoy et al 4.

There were multiple black pigmented gallstones ranging from 0. Xanthogranulomatous cholecystitis is a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma. Therefore, before the operation, differential diagnosis of XGC and gallbladder cancer by percutaneous needle biopsy might be helpful in planning the appropriate operative procedure.

The reason for this association is not clear.

Xanthogranulomatous cholecystitis

Nippon Geka Gakkai Zasshi. Clinical manifestations of XGC are usually those of acute or chronic cholecystitis, but some patients present anorexia, nausea, vomiting, right upper quadrant pain and mass, suggesting gallbladder cancer.

Pathology of Xanthogranulomatous Cholecystitis. J Clin Pathol 40 4: We report a case with XGC xanthogranulomxtous gallbladder cancer in a hemophilia patient. There was a small-sized abscess in xanthogranilomatous gallbladder wall near the cystic duct. Histopathological study and classification. Images hosted on other servers: Xanthogranulomatous cholecystitis ; Gallbladder cancer. It has been suggested that XGC is initiated by a chronic inflammation and obstruction.

Ceroidlike histiocytic granulomas of gallbladder.

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