Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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However, and despite the widespread use of these plants in Moroccan traditional folk medicine, to the best of our knowledge, no information has been previously reported on the anticancer activity of Moroccan Cotula cinerea and Salvia verbenaca.

Further investigations regarding the identification of bio-actives molecules responsible for these effects are needed. Cotula is known to be used in New Zealand as ground cover for bowling greens, playing fields on which the ball-game of bowls is played [6] [7].

Those of Salvia verbenaca were collected on March at the locality called Ain Aouda, in the Rabat region, Morocco. Cotula cotuloides Steetz Druce Cotula cryptocephala Sch. Koch Cotula cinereum Cotula coronopifolia L. The species within this genus can vary extensively in their habitleaf divisioninvolucrereceptacle and achenes. Indeed, plants are rich sources of new compounds from which some secondary metabolites have been shown to possess anticancer properties [ 5 — 7 ].

Skip to search form Skip to main content. This makes it difficult to define them by comparing their morphology.

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Moreover, a molecule could have an effect on one type of tumor and not on others. Due to its complex phytochemical composition, it is difficult to define a unique mechanism of its action on the used cell tumor.

Indeed, the antitumor properties of phenolic compounds and flavonoids against several cell lines representing numerous human cell lines have been previously reported [ 6 ].

On the other hand, different results were obtained and Cotula cinerea essential oil was the coula cytotoxic with the lowest IC 50 value The sections possess different basic chromosome numbers:. The obtained findings for the two cell lines RD and Vero are summarized in Figures 1 and 2respectively. Exploring alternative sources of new antitumor agents with specific targets is thus imperative and of great and crucial importance.


After filtration and evaporation of ethanol, the obtained aqueous solution was successively fractionated with hexane, ethyl acetate, and n -butanol. The collected aerial parts were left under shade at room temperature until complete drying. Traditional forms of medicine, especially the herbal products deployed for centuries in many parts of ctula world, could be good alternative for scientific investigation due to their attributes against cotjla cell lines.

BioMed Research International

The obtained results raise then the possibility of a potential use of Cotula cinerea as a source of potent anticancer products.

Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ]. Views Read Edit View history.

The plant is widely distributed in Morocco and is widely used in Moroccan traditional folk medicine as a cholagogue, antiseptic, diuretic, and astringent [ 12 ]. In the case the RD cell line, the lowest IC 50 value Growing Wildly in the Middle East: The exact mechanisms through which such compounds act in their cytotoxicity effect are not well known, but some tentative investigations suggested that these compounds could interrupt the life cycle cell, inducing the apoptosis cimerea and inactivating the telomerase [ 6 ].

In the genus was subdivided by George Bentham [5] into three sections. The results are expressed as percentage of cytotoxicity versus the concentrations vinerea the essential oil or extracts of both plants. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. This was followed by the ethyl acetate extract and the essential oil with moderate effects against RD cell line and showed IC 50 values of The exact mechanism through which the explored extracts act on each tumor cell line is obviously difficult to highlight.


For the town, see Cotula, Tennessee. El Btaouri et al. Examination of the cytotoxic activity of the Cotula cinerea individual compounds would give crucial information regarding the exact mechanism of this plant in antitumor activity.

Ccotula of 22 references. The main constituents of the essential oil are Camphor, Camphene, Alpha-pinene, 3-carene, Thujone, 4-terpineol, Z -betafarnesene and santolinatriene.

These corollas may be tubular, reduced or even absent. To date various bioactive compounds have been tried against cancer. For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used cotla was observed indicating a dose dependent effect. Cotula socialis Hilliard Cotula sororia DC.

Cotula — Wikipédia

Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. Cotula australis Sieber ex Spreng. A potent cytotoxicity was thus observed for the Cotula cinerea hexane extract which inhibited the growth of RD cell line at the lowest IC 50 value Oils, Volatile Search for additional papers on this topic. These plants are widely used in the Moroccan traditional folk medicine.

Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect. Evaluation of the Cytotoxicity Before evaluating the antiproliferative activity, the cellular density of each species was determined using light microscopy. Gymnogyne Steetz Peyrousea DC.

The biological activity of C. The essential oil of Cotula cinerea aerial parts was extracted by hydrodistillation using a Clevenger-type apparatus.

Comparison of the obtained results for both cell lines showed that Cotula cinerea extract activity was higher than its corresponding Salvia verbenaca one. The noticed differences in the observed cytotoxicity of the investigated mixtures could obviously be due to the phytochemical composition of each extract.

Most are disciform lacking ray florets. Cotula vulgaris Levyns Cotula zeyheri Fenzl.

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