Niño de 3 meses con anemia hemolítica no autoinmune. Article in Anales de Pediatría 55(3)– · December with 6 Reads. Article in Anales de Pediatría 71(3) · September with 56 Reads Anemia hemolítica autoinmune con prueba de antiglobulina positiva a. de Medicina Interna de una institución pediátrica de alto nivel de complejidad. El paciente consultó por un cuadro de anemia hemolítica autoinmune.
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Double blind peer review. A mediana de seguimento foi de 11 meses 5 a 23 meses.
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Autoimmune hemolytic anemia is characterized by the production of autoantibodies against erythrocyte membrane antigens. This study was carried out to identify the clinical, immunological and outcome characteristics of autoimmune hemolytic anemia patients treated at the HC-UFMG Pediatric Hematology Unit and the Hemocentro de Belo Horizonte.
We evaluated 17 patients younger than 15 years old admitted from to were evaluated. Autoimmune hemolytic anemia diagnosis was based on the presence of acquired hemolysis and confirmed by positive direct Coombs polyspecific test results.
Clinical, laboratory, and outcome data were obtained from patient records. Autojnmune median age at diagnosis was The direct Coombs polyspecific test was positive in 13 and negative in four patients.
Monospecific testing was performed for 14 patients. The most frequent red cell autoantibody was IgG five patientsfollowed by IgM in two. Thirteen patients had severe anemia and needed blood transfusions.
Treatment of autoimmune hemolytic anemias
Underlying diseases were identified in four patients: The remaining patients were classified as having primary disease. The median follow-up period was 11 months 5 to 23 months. Three children died, two after splenectomy and one with complications of the underlying disease.
Autoimmune hemolytic anemia is rare in children and adolescents. Prognosis is worse in patients with hemolitlca underlying diseases. Journal Homepage Journal Title: Brazilian Society of Pediatrics. Pediatrics Country of publisher: Netherlands Language of fulltext: English Full-text formats available: Funding for sustainable Open Access incl. Our members Our publisher members Our sponsors Our volunteers.