Palmoplantar keratodermas (PPKs) are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. What are the other Names for this Condition? (Also known as/Synonyms). Acquired Palmoplantar Keratoderma; Acquired PPK. Paraneoplastic palmoplantar keratoderma (PPK) is an acquired dermatosis that presents with hyperkeratosis of the palms and soles in association with visceral.

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It is associated with squamous cell carcinoma of the upper aerodigestive tract oral cavity, pharynx, larynx, oesophagus.

Acquired palmoplantar keratoderma.

Palmoplanta no such etiology is evident, then conservative treatment options include topical keratolytics urea, salicylic acid, lactic acidrepeated physical debridement, topical retinoids, topical psoralen plus UVA, and topical corticosteroids.

The palms of the hands may be affected with discrete, centrally placed lesions. Occasionally keratoderma can affect other parts of the body It can be difficult to differentiate between the different types of keratoderma, however, the management principles are similarand as such the key diagnostic elements are to exclude the rare malignant or other systemic causes. The vast majority are associated with adenocarcinoma of the stomach, but other malignancies sometimes found include other GI tract tumours, lung, uterus, ovaries, and urinary tract Tripe palms – the appearance differs to that of keratoderma with thickened velvety palms that have the appearance of tripe.

Clinical classification Keratoderma can be defined by its clinical appearance, although there is often overlap: All named individuals and organisations maintain copyright for the relevant images. Website author — Dr Tim Cunliffe read avquired. Some people with focal palmoplantar keratoderma also have abnormalities of the fingernails and toenails There are several inherited typeswhich are all rare.


Keratoderma can be inherited, acquired, and rarely, paraneoplastic ie secondary to an internal malignancy. Keratoderma may be hereditarywith symptoms presenting in early childhood, or acquired when pamoplantar presents in later life. Rarely keratoderma pa,moplantar be associated with malignancy. Palmoplantar keratoderma is a term used to define a marked thickening of the skin on the palms and soles, either as a focal entity, or diffuse.

To facilitate such evaluations, this review categorizes the acquired PPKs as: The first step should include a comprehensive history and a physical examination, including a complete skin examination. If no pertinent findings are identified after a history and a physical examination, laboratory and radiology studies should be undertaken in a systematic, logical fashion. Web Design – Mode Ten Designs. In order to avoid the possibility of overlooking an underlying etiology and to eliminate excessive testing, we present an algorithm for assessing patients presenting with acquired PPK.

The cutaneous features usually pre-date the diagnosis of the cancer. Please click on images to enlarge or download.

Palmoplantar keratoderma

If findings are consistent with a hereditary keratoderma, then a genetics consultation should be considered. It is often associated with acanthosis nigricans AN. Axial CT images showing multiple polypoidal enhancing mass lesions with surface calcifications, in the urinary bladder.

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Etretinate and acitretin have also shown some success as alternative treatments in recalcitrant cases. This chapter provides a practical overview of keratoderma, and is set out as below: Given the numerous possible underlying causes for acquired PPKs, evaluation of patients presenting with acquired PPK can be a perplexing task.


Acquired keratoderma | DermNet NZ

Three stages have been described: Please follow this link if you have any high-quality images that you can contribute to the website. Keratoderma of the soles and acanthosis nigricans of the hands in a patient with bladder carcinoma. A painful paronychia develops with no evidence of bacterial or fungal infection.

All are rare Epidermolytic keratoderma Palmop,antar keratoderma and non-epidermolytic keratoderma Thost-Unna keratoderma are two of the best described forms Both are autosomal dominant Clinically the features can be indistinguishable with the development, usually in infancy, of diffuse, yellow, thickened skin affecting the palms and soles.

They can be very effective for some patients, but cannot be used in fertile women due to their teratogenicity.

It usually affects the sole of the feet around the margins of the heel and under the metatarsal heads. Aetiology Clinical findings Images Investigations Management. Any findings suggestive keratodemra underlying conditions should be aggressively evaluated and treated.

There is usually a well-defined erythematous border The two conditions vary in their histological features Several others types have been described. In cases where tripe palms occur without AN, lung cancers are usually responsible.

Acquired palmoplantar keratoderma.

Palmoplantar keratodermas PPKs are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. In terms of treatment, the most successful pwlmoplantar occur when the underlying etiology is diagnosed and treated.

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