Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.
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Related Topics in Pharmacology. A teratogen is a drug that interferes with the development of a fetus.
Fetal hydantoin syndrome – Wikipedia
Symptoms of the following disorders can be similar to those of fetal hydantoin syndrome. Differential Diagnosis Fetal Alcohol Syndrome. Researchers believe that the protein product of this gene plays a role in the proper breakdown metabolism of phenytoin or one of its metabolites.
Some infants and children may experience delays in reaching developmental milestones such as learning to sit up or crawl developmental delays.
Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years NEAD study: The concept of fetal antiepileptic syndromes in this regard is less useful than in the past and the broad consideration of the major and minor congenital malformations, various cognitive impairments, and behavioral abnormalities taken as a broader, collective concept is more appropriate.
All studies receiving U. Summary and related texts. Oguni M, Osawa M.
Front profi le Click here to view. Related Bing Images Extra: Chronic developmental exposure to phenytoin has long-term feral consequences. Also, it is recommended that women taking phenytoin take folic acid supplements, both before conception and during pregnancy as a preventive measure against malformations.
General Discussion Summary Fetal hydantoin syndrome is a characteristic pattern of mental and physical birth defects that results from maternal use of the anti-seizure anticonvulsant drug phenytoin Dilantin during pregnancy.
Studies have indicated that fetal valproate syndrome is associated with greater risk of fetsl and cognitive abnormalities than other anti-seizure medications. Anti-seizure medications, also known as antiepileptic or anticonvulsant medications are among the most common teratogens prescribed to women of childbearing age. Inguinal hernia is when a portion of the intestines pushes through the muscular layers of the abdominal wall.
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Right side in occlusion Click here to view. Elsevier Saunders, Philadelphia, PA; These images are a random sampling from a Bing search on the term “Fetal Hydantoin Syndrome.
Association with EPHX1 has been suggested. Affected infants may also exhibit stiff, tapered fingers, underdeveloped fingers and toes, toes that resembled fingers digitalized toesand malformed, underdeveloped fingernails and toenails.
Fetal antiepileptic drug exposure: Fetal hydantoin syndrome and its anaesthetic implications: This page was last edited on 17 Decemberat Sridharan R, Murthy BN. Counseling is recommended for women to discuss the risks that seizures prevent for both the developing fetus and the expectant mother as well as the risks to the developing fetus involved with taking anti-seizure medications during pregnancy.
Definition NCI A teratogenic disorder observed in a newborn or child of a mother who was exposed to phenytoin during pregnancy. Coffin-Siris syndrome CSS is a rare genetic disorder that may be evident at birth congenital.
Years Published, Infants with fetal hydantoin syndrome can benefit from early developmental intervention to ensure that feal children reach their potential. Genetic differences in formation of these free radicals, drug clearance, fetql repair mechanisms may explain different susceptibility across individuals.
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Less commonly, microcephaly, ocular defects, oral clefts, umbilical and inguinal hernias, hypospadias and cardiac anomalies have also been reported. The documents contained in this web site are presented for information purposes only. World Health Organization; Affected children may benefit from occupational, physical and speech therapy.
Symptoms may not be noticeable at birth congenitalbut will become apparent as an affected child grows older. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted.
Therefore, it is important to note that affected individuals may not have all of the symptoms discussed below. A second surgery is sometimes necessary for cosmetic purposes when the child is older.
Only comments written in English can be processed. For information about clinical trials conducted in Europe, contact: Infants with fetal valproate syndrome are at a greater risk of developing neurological abnormalities than are infants whose mothers took other types of anti-seizure medications. Prevention It is recommended that women be treated with a single fwtal prior to conception and throughout pregnancy, since it appears that children exposed syndroke multiple anticonvulsants may be at a greater risk for significant birth defects.
D ICD – Treatment for epilepsy in pregnancy: