Tropical sprue is an acquired chronic diarrheal disorder of unclear etiology affecting residents of and visitors to tropical regions. Patients usually present with . English Spanish online dictionary Term Bank, translate words and terms with different pronunciation options. ESPRUE TROPICAL trastorno de diarrea crónica con mala absorción y deficiencia nutricional etiología desconocida regiones tropicales.

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Curr Gastroenterol Rep ; 3: Am J Med 89 — Malabsorbed nutrients with osmotic diarrhoea; colonic water secretion due to unabsorbed fatty acids. Indian J Gastroenterol 23 94— Tropicao the process, it has become an extremely significant disease because it is a classical example of a malabsorptive process, and has shed considerable light on intestinal physiology and on other malabsorption syndromes.

Crohn’s disease is increasingly being diagnosed in tropical countries, 535455 and is an important differential diagnosis for tuberculosis. Tropical sprue is an acquired disease of unknown aetiology, characterised by malabsorption, multiple nutritional deficiencies and mucosal abnormalities in the small bowel.

What is tropical sprue? Primary immunodeficiency syndromes Common variable immunodeficiency occurs sporadically in residents of the tropics, and may present primarily as a malabsorption syndrome.

Answers F, false, T, true 1. A description in the ancient Indian medical treatise, Charaka samhitaof an illness characterised by chronic diarrhoea and weight loss and attributed to failure of the digestive system 1 suggests that the malabsorption syndrome was clinically recognised in the tropics two millennia ago.


Malabsorption syndrome in India. Definition Tropical sprue is a primary malabsorption syndrome that runs a chronic relapsing course. Stool cultures are rarely diagnostic in this setting but are performed in selected patients. Indian J Med Res — Fever, uncommon in Caribbean patients, has been noted in almost a quarter of patients from southern India.

InWilliam Hillary described a malabsorption syndrome in expatriates living in Barbados, 2 but the first case that he described may have been due to giardiasis rather than tropical sprue. J HIV Ther 7 17— Nat Rev Gastroenterol Hepatol. Follow-up biopsies in 6 patients demonstrated a histologic response after oral folates and doxycycline treatment.

Best Pract Res Clin Gastroenterol 19 — Restoration of fluid and electrolyte balance is necessary in dehydrated patients, and deficiencies of magnesium and potassium need to be corrected in those with longstanding illness. Infection with S stercoralis is common in the tropics and may cause chronic diarrhoea and malabsorption in immunocompetent people.

Gut 30 17— HLA and tropical sprue. Gut 23 — Infect Immun 72 — This is identified by quick response to treatment with tropicl or other antibiotics. Am J Clin Nutr 25 — Vitamin B 12 malabsorption may be noted in some people due to lack of pancreatic proteolytic activity and failure to cleave the R protein—vitamin B 12 complex.

Tropical malabsorption

Lancet 1 13— Bacterial colonisation of jejunal mucosa in acute tropical sprue. Dig Dis 22 — It appears to be a more severe form of environmental enteropathy. Morphologic characteristics of jejunal ttropical from asymptomatic Haitians and Puerto Ricans. Specific deficiencies of vitamins A and D and the B complex vitamins may be treated with either parenteral or oral supplements.


Pancreatic disease Tropical pancreatitis Idiopathic chronic calcific pancreatitis is endemic in several tropical regions including the Indian subcontinent and southern Africa. Epidemics in southern India have occurred. Two abnormal tests in the appropriate setting are consistent with tropical sprue in the absence of other causes of malabsorption. Esprrue Gastroenterol Rep ; 7: T cells possibly have a role in the development of enteropathy.

An endoscopic, histological and microbiological study. Ultrastructural studies show degenerating cells in the crypts of the small intestine, suggesting stem cell damage. Treatment with thiabendazole, albendazole or ivermectin has been found to be effective.

It may follow as a sequel to epidemics of acute gastroenteritis. Other conditions which can resemble tropical sprue need to be differentiated.

Tropical malabsorption

Braz J Infect Dis 7 16— Malabsorption of fat, vitamin B 12 and xylose, as well as increased mucosal permeability, has been noted in a large number of healthy residents of the tropics. Viral particles resembling human enteric corona viruses have been identified in the stool of patients with tropical sprue.

A perspective on tropical sprue.

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