Request PDF on ResearchGate | Dermatitis granulomatosa intersticial con artritis | —Interstitial granulomatous dermatitis with arthritis is a systemic disease. La dermatitis granulomatosa intersticial con artritis es una enfermedad sistémica que afecta a la piel y al sistema musculosquelético. Esta nueva entidad se. Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible from the Additional.

Author: Vurr Gam
Country: Reunion
Language: English (Spanish)
Genre: Science
Published (Last): 22 February 2011
Pages: 227
PDF File Size: 9.31 Mb
ePub File Size: 16.81 Mb
ISBN: 563-5-84702-593-2
Downloads: 42826
Price: Free* [*Free Regsitration Required]
Uploader: Dazshura

Granulomatous dermatitis

Myelodysplastic syndrome presenting as generalized granulomatous dermatitis. Services on Demand Article. The characteristic histological features of granuloma annulare are:.

Am J Dermatopathol ; 30 2: This new entity is characterized by the formation of cords in a linear or arcuate grsnulomatosa, although a wide range of clinical presentations has been described. Interstitial granulomatous dermatitis with plaques.

Several granulomayosa have been noted to arise in association with interstitial granulomatous dermatitis.

We describe two new cases with their clinical and histopathological characteristics, which fit into the clinical presentation spectrum of this pathology.

Granulomatous dermatitis | DermNet NZ

The typical microscopic presentation should be that of a granulomatous dermatitis, with palisading or interstitial histiocytes, variable numbers of neutrophils and eosinophils, and scattered areas of degenerating collagen bundles. Its clinical manifestations are variable. Os restantes exames laboratoriais revelaram hipotiroidismo e anticorpos anti-tiroideus positivos. March Pages Clin Rheumatol Sayah A, English JC. Interstitial granulomatous dermatitis with arthritis.

Received Nov 12; Accepted Nov Our patient showed decreased levels of free thyroxine and high titers of anti-thyroid antibodies, disclosing a previously unrecognized autoimmune thyroiditis. National Center for Biotechnology InformationU.

In addition, there is a variable amount of polymorphonuclear leukocytes in the infiltrate. J Am Acad Dermatol ; She denied any systemic complaints, emergency laboratory tests revealed only microcytic anemia and slightly elevated C-reactive protein interstiicial, therefore, she was discharged and prescribed only conservative measures. Show more Show less.


Article in xml format Article references How to cite this article Automatic translation Send this article by e-mail. Egas Moniz Lisboa, Portugal E-mail: Successful treatments have included:. Several different types of rash have been described granulojatosa the same histological appearance including annular plaques on the trunk.

Interstitial granulomatous dermatitis with arthritis is a rare rheumatologic disease characterized by the occurrence of inflammatory arthritis in association with large, erythematous, symmetrical cutaneous lesions ranging from typical, but infrequent, cord-like lesions on the flanks to more common violaceous plaques on the trunk and limbs featuring a typical histologic infiltrate mainly constituted of histiocytes.

Dermatitis granulomatosa intersticial con artritis | Actas Dermo-Sifiliográficas (English Edition)

The granulomatous reaction pattern. Interstkcial Bassas aPablo Umbert b. Although TNF-inhibitors have been recently described as inducing interstitial granulomatous dermatitis7 etanercept has been used in interstitial granulomatous dermatitis associated with rheumatoid arthritis with complete skin clearance and improvement in arthritis. The features of interstitial granulomatous dermatitis are variable.

It has been reported in association with several drugs, lymphoproliferative diseases and autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus and vasculitis, but association with autoimmune thyroiditis is rare. Interstitial granulomatous dermatitis was initially described by Ackerman et al in In once case, the lesions cleared after lung cancer was treated. It represents a disorder that involves degeneration of collagen by immune complex-mediated formation and deposition on the endothelial surface.

In the year has been indexed in the Medlinedatabase, and has become a vehicle for expressing the most current Spanish medicine and modern. However, despite normalization of thyroid function, there was only transitory improvement of individual lesions, and, after a follow-up of 2 years, new lesions keep on occurring Figure 4.

Although the original manifestation had been described as subcutaneous linear nodules, also known as rope sign 1later reports showed a clinical spectrum quite heterogeneous which vary from hyperpigmented, erythematous papules, subcutaneous plaques, annular lesions to firm red-purplish nodules as observed in our patient.


Differential diagnosis includes other entities related to rheumatoid arthritis, such as rheumatoid nodules, rheumatoid vasculitis, palisaded neutrophilic and granulomatous dermatitis, in addition to rheumatoid neutrophilic dermatosis, which, unlike the latter, presents neutrophilic dermal infiltrate and leukocytoclasia without vasculitis under histopathology.

Am J Dermatopathol ; 33 8: Interstitial granulomatous dermatitis with arthritis. This article has been cited by other articles in PMC. The dermatosis is traditionally asymptomatic.

There was a problem providing the content you requested

How to cite this article. Both forms of granulomatous dermatitis have often arisen in people with other conditions considered autoimmune in origin, implying an immune-complex mechanism may be involved in the pathogenesis. Histological features include dense dermal histiocytic infiltrate, usually in a palisade configuration, and scattered neutrophils and eosinophils.

A year-old Caucasian female presented to the emergency room with 2 erythematous, sharply demarcated, painful, indurated plaques, on her left arm and right thigh, which had appeared in the previous 48 hours. It is usually related to rheumatoid arthritis or another autoimmune disease. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Granulomatous dermatitis typically flares and remits. Histologically, a diffuse interstitial infiltrate with histiocytes and foci of collagen degeneration is seen, as well as the formation of small granulomas around these areas of degeneration.

Support Center Support Center.

Skin biopsy was compatible with interstitial granulomatous dermatitis. Besides being an uncommon clinicopathological entity, interstitial granulomatous dermatitis, also described as interstitial granulomatous dermatitis with arthritis IGDAhas shown a wide spectrum of clinical manifestations, such as linear and erythematous lesions, papules, plaques and nodules.

iPhone X